Atypical hemolytic uremic syndrome (aHUS) is a heterogeneous disorder characterized by microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and acute kidney injury (AKI).In about 50% of cases, pathogenic variants in genes involved in the innate immune response including complement factors complement factor H (CFH), CFI, CFB, C3, and membrane
IntroductionHigh horseshoe-shaped anal fistula (HHAF) is a complicated and challenging condition that presents considerable obstacles in treatment.We are presently investigating a novel surgical technique involving a combination of multi-incision and tube-dragging therapy, and laser closure (MITD-LaC) for the management of HHAF.Due to the current s
The widespread phenomenon of unsafe food on the Chinese market has been argued to be both symptomatic of moral disregard for the well-being of strangers and productive of social distrust.Organic farming has grown in recent years in response to this situation, and this article discusses the ethical work of farmers based on ethnographic fieldwork con
While it is clear Headwear that acute hippocampal injury or status epilepticus increases the production of new neurons in the adult dentate gyrus (DG), the effects of chronic epilepsy on dentate neurogenesis are unknown.We hypothesize that epileptogenic changes and spontaneous recurrent motor seizures (SRMS) that ensue after hippocampal injury or s
Polyketides are biosynthesized through consecutive Towel Racks decarboxylative Claisen condensations between a carboxylic acid and differently substituted malonic acid thioesters, both tethered to the giant polyketide synthase enzymes.Individual malonic acid derivatives are typically required to be activated as coenzyme A-thioesters prior to their